Status:

RECRUITING

Causes and Outcomes of Febrile Illness in Health Facilities in Rural South and Southeast Asia

Lead Sponsor:

University of Oxford

Collaborating Sponsors:

Shoklo Malaria Research Unit (SMRU)

Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit

Conditions:

Acute Febrile Illness

Eligibility:

All Genders

29+ years

Brief Summary

This prospective multi-site observational study aims to describe causes and clinical outcomes of acute febrile illness as well as host biomarkers in patients aged \>28 days residing in rural areas in ...

Detailed Description

The majority of people in low- and middle-income countries (LMICs) in South and Southeast Asia live in rural areas. These people are some of the poorest in the region and the exact health issues which...

Eligibility Criteria

Inclusion Criteria:

  1. The patient and/or where relevant their parent/guardian/caretaker is willing and able to give informed consent /assent for participation in the study;
  2. Aged > 28 days (day of birth = Day 1);
  3. Axillary temperature at presentation (≥ 37.5°C (99.5°F) OR < 35.5°C (95.9°F)) and no more likely cause than sepsis for hypothermia OR History of fever in the 24 hours prior to presentation;
  4. Onset of illness ≤ 14 days

Exclusion Criteria:

  1. Accident or trauma is the cause for the patient's presentation;
  2. Presentation ≤ 3 days after routine immunisations
  3. Is currently under follow-up or has been afebrile for less than 72 hours after completion of a follow-up period.
  4. The treating healthcare worker's decision is to send the patient home following initial assessment.

Key Trial Info

Start Date :

June 21 2022

Trial Type :

OBSERVATIONAL

Allocation :

ESTIMATED

End Date :

December 1 2026

Estimated Enrollment :

7200 Patients enrolled

Trial Details

Trial ID

NCT04629053

Start Date

June 21 2022

End Date

December 1 2026

Last Update

January 12 2026

Active Locations (4)

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Page 1 of 1 (4 locations)

1

Building Resources Across Communities (BRAC)

Dhaka, Bangladesh, 1212

2

Laos-Oxford-Mahosot Wellcome Trust Research Unit

Vientiane, Laos, 01000

3

Shoklo Malaria Research Unit

Mae Sot, Changwat Tak, Thailand, 63110

4

Chiangrai Clinical Research Unit (CCRU)

Chiang Rai, Thailand, 57000

Causes and Outcomes of Febrile Illness in Health Facilities in Rural South and Southeast Asia | DecenTrialz