Status:
RECRUITING
Causes and Outcomes of Febrile Illness in Health Facilities in Rural South and Southeast Asia
Lead Sponsor:
University of Oxford
Collaborating Sponsors:
Shoklo Malaria Research Unit (SMRU)
Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit
Conditions:
Acute Febrile Illness
Eligibility:
All Genders
29+ years
Brief Summary
This prospective multi-site observational study aims to describe causes and clinical outcomes of acute febrile illness as well as host biomarkers in patients aged \>28 days residing in rural areas in ...
Detailed Description
The majority of people in low- and middle-income countries (LMICs) in South and Southeast Asia live in rural areas. These people are some of the poorest in the region and the exact health issues which...
Eligibility Criteria
Inclusion Criteria:
- The patient and/or where relevant their parent/guardian/caretaker is willing and able to give informed consent /assent for participation in the study;
- Aged > 28 days (day of birth = Day 1);
- Axillary temperature at presentation (≥ 37.5°C (99.5°F) OR < 35.5°C (95.9°F)) and no more likely cause than sepsis for hypothermia OR History of fever in the 24 hours prior to presentation;
- Onset of illness ≤ 14 days
Exclusion Criteria:
- Accident or trauma is the cause for the patient's presentation;
- Presentation ≤ 3 days after routine immunisations
- Is currently under follow-up or has been afebrile for less than 72 hours after completion of a follow-up period.
- The treating healthcare worker's decision is to send the patient home following initial assessment.
Key Trial Info
Start Date :
June 21 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
7200 Patients enrolled
Trial Details
Trial ID
NCT04629053
Start Date
June 21 2022
End Date
December 1 2026
Last Update
January 12 2026
Active Locations (4)
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1
Building Resources Across Communities (BRAC)
Dhaka, Bangladesh, 1212
2
Laos-Oxford-Mahosot Wellcome Trust Research Unit
Vientiane, Laos, 01000
3
Shoklo Malaria Research Unit
Mae Sot, Changwat Tak, Thailand, 63110
4
Chiangrai Clinical Research Unit (CCRU)
Chiang Rai, Thailand, 57000