Status:

RECRUITING

4D-MRI for Precision Medicine

Lead Sponsor:

University of Virginia

Collaborating Sponsors:

Duke University

The Hong Kong Polytechnic University

Conditions:

Healthy Volunteers

Liver Cancer

Eligibility:

All Genders

18-82 years

Brief Summary

The purpose of this study is to develop new ways to make medical images of the lungs and liver of adults using a technique called four-dimensional magnetic resonance imaging (4D-MRI). This technique p...

Detailed Description

Radiotherapy for cancer has been a forerunner of personalized medicine, developing individualized treatments based on patient-specific anatomical information. Despite many advances in radiotherapy ove...

Eligibility Criteria

Inclusion Criteria:The inclusion criteria for lung and liver cancer patients are:

  • Patient is 21 or older
  • Patient has primary or metastatic tumor(s) in the lungs or the liver
  • Diameter of the tumor(s) is less than 7 cm
  • Patient will receive radiation therapy (ordered by the treating Radiation Oncologist) as part of their treatment regimen
  • Patient will undergo a planning CT scan with tumor motion assessment (planning 4D-CT ordered by the treating Radiation Oncologist) as part of their treatment regimen
  • Patient has signed informed consent and is willing to comply with the 4D-MRI imaging protocol

The inclusion criteria for healthy volunteers are:

  • Subject is 18 or older
  • Subject has signed informed consent and is willing to comply with the 4D-MRI imaging protocol

Exclusion Criteria:

  • Any condition for which a MRI procedure is contraindicated including presence of metallic material in the body, such as pacemakers, non- MRI compatible surgical clips, shrapnel, etc.
  • Subjects who have difficulty lying flat on their back for extended periods of time
  • Patients with any serious/poorly controlled medical or psychological conditions that would complicate protocol compliance
  • Too large to adequately fit in the magnet bore or RF coils
  • Claustrophobia
  • Females who are pregnant or lactating
  • Presence of active or chronic infection

Key Trial Info

Start Date :

November 5 2020

Trial Type :

OBSERVATIONAL

Allocation :

ESTIMATED

End Date :

December 31 2030

Estimated Enrollment :

100 Patients enrolled

Trial Details

Trial ID

NCT04657042

Start Date

November 5 2020

End Date

December 31 2030

Last Update

March 24 2025

Active Locations (1)

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1

University of Virginia

Charlottesville, Virginia, United States, 22908