Status:
COMPLETED
The Prognostic Impact of Selenium On Critical Surgical Patients
Lead Sponsor:
Chang Gung Memorial Hospital
Conditions:
Critical Illness
Selenium Deficiency
Eligibility:
All Genders
20+ years
Phase:
PHASE4
Brief Summary
Selenium is an important trace element for human for its multiple roles such as the antioxidant activity. Previous evidences showed that critically ill patients may benefit from selenium supplement bu...
Detailed Description
Acute abdomen is a common surgical emergency and is often the result of peritonitis due to an acute inflammatory process within abdominal cavity. Many of the patients with acute abdomen have severe se...
Eligibility Criteria
Inclusion
- Intensive care unit (ICU) patients receiving abdominal surgeries for acute abdomen
- within 48 hours post-operatively
- stay in ICU for more than 48 hours
- meets sepsis criteria of Sepsis-3 (2016)
Exclusion
- liver cirrhosis Child-Pugh score B or C
- breastfeeding or pregnancy
- allergy yo selenium
- vegetative status or irreversible diseases with life-expectancy fewer than 28 days
- End-stage renal disease under dialysis
- Human immunodeficiency virus infection
- neutropenia not due to sepsis (granulocyte \< 1000/mm3)
- Heart failure (New York Heart Association class III-IV) or recent myocardial infarction (within 6 weeks)
- post cardiopulmonary cerebral resuscitation within 4 weeks
- taking immunosuppressants
- receiving anti-cancer therapy
- signed do not resuscitation
- joined other clinical research
Key Trial Info
Start Date :
December 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 16 2022
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT04662242
Start Date
December 1 2020
End Date
November 16 2022
Last Update
February 10 2023
Active Locations (1)
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1
Chang Gung Memorial Hospital
Taoyuan District, Taiwan, 333