Status:

ACTIVE_NOT_RECRUITING

Efficacy and Safety of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) Plus Chemotherapy in Participants With Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-7902-015/E7080-G000-321/LEAP-015)

Lead Sponsor:

Merck Sharp & Dohme LLC

Collaborating Sponsors:

Eisai Inc.

Conditions:

Advanced/Metastatic Gastroesophageal Adenocarcinoma

Eligibility:

All Genders

18+ years

Phase:

PHASE3

Brief Summary

The purpose of this study is to assess the efficacy and safety of lenvatinib (E7080/MK-7902) plus pembrolizumab (MK-3475) plus chemotherapy compared with chemotherapy alone in participants with advanc...

Detailed Description

There will be 2 parts to the study: a Safety Run-in (Part 1) and the Main Study (Part 2). In Part 1 (Safety Run-in), approximately 12 participants will be treated with lenvatinib in combination with p...

Eligibility Criteria

Inclusion

  • Has histologically and/or cytologically confirmed diagnosis of previously untreated, locally advanced unresectable or metastatic gastroesophageal adenocarcinoma
  • Is not expected to require tumor resection during the treatment course
  • Has gastroesophageal adenocarcinoma that is not human epidermal growth factor receptor 2 (HER-2)/neu positive
  • Has measurable disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 by scan with IV contrast as determined by the local site investigator
  • Male participants agree to refrain from donating sperm and agree to either remain abstinent from heterosexual intercourse as their preferred and usual lifestyle OR agree to use contraception, during the intervention period and for ≥7 days after last dose of lenvatinib or 90 days after last dose of chemotherapy-whichever comes last
  • Female participants not pregnant or breastfeeding are eligible to participate if not a women of childbearing potential (WOCBP), or if a WOCBP they either use a contraceptive method that is highly effective OR remain abstinent from heterosexual intercourse as their preferred and usual lifestyle, and do not donate eggs (ova, oocytes) to others or freeze/store for their own use, and abstain from breastfeeding during the intervention period through 120 days after last dose of pembrolizumab, 30 days after last dose of lenvatinib, or 180 days after last dose of chemotherapy-whichever occurs last
  • Has a performance status of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG) Performance Scale within 3 days prior to the first dose of study treatment
  • Has adequately controlled blood pressure with or without antihypertensive medications
  • Has adequate organ function

Exclusion

  • Has had previous therapy for locally advanced unresectable or metastatic gastric/gastroesophageal junction (GEJ) esophageal adenocarcinoma
  • Has had major surgery within 28 days prior to first dose of study interventions
  • Has had radiotherapy within 14 days of randomization
  • Has a known additional malignancy that is progressing or has required active treatment within the past 5 years
  • Has known central nervous system (CNS) metastases and/or carcinomatous meningitis
  • Has severe hypersensitivity (≥Grade 3) to treatment with an monoclonal antibody (mAb) or known sensitivity or intolerance to any component of lenvatinib, pembrolizumab, study chemotherapy agents and/or to any excipients, murine proteins, or platinum containing products
  • Has had an allogeneic tissue/solid organ transplant
  • Has perforation risks or significant gastrointestinal (GI) bleeding
  • Has GI obstruction, poor oral intake (CAPOX participants), or difficulty in taking oral medication (CAPOX participants)
  • Has received prior therapy with an anti-programmed cell death 1 (PD-1), anti-PD-L1, or anti-PD-L2 agent or with an agent directed to another stimulatory or coinhibitory T-cell receptor
  • Has received prior therapy with anti- vascular endothelial growth factor (VEGF) tyrosine kinase inhibitor or anti-VEGF mAb
  • Has received a live or live-attenuated vaccine within 30 days before the first dose of study drug
  • Has an active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs)
  • Has radiographic evidence of encasement or invasion of a major blood vessel, or of intratumoral cavitation
  • Has inadequate cardiac function
  • Has a history of (noninfectious) pneumonitis/interstitial lung disease that required steroids or has current pneumonitis/interstitial lung disease
  • Has poorly controlled diarrhea
  • Has accumulation of pleural, ascitic, or pericardial fluid requiring drainage or diuretic drugs within 2 weeks prior to enrollment
  • Has peripheral neuropathy ≥Grade 2
  • Has a known history of human immunodeficiency virus (HIV) or HIV 1/2 antibodies
  • Has a known history of hepatitis B (defined as HBsAg reactive) or known active hepatitis C virus (defined as HCV ribonucleic acid (RNA) \[qualitative\] is detected) infection
  • Has weight loss of \>20% within the last 3 months

Key Trial Info

Start Date :

December 30 2020

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

March 31 2026

Estimated Enrollment :

895 Patients enrolled

Trial Details

Trial ID

NCT04662710

Start Date

December 30 2020

End Date

March 31 2026

Last Update

November 28 2025

Active Locations (177)

Enter a location and click search to find clinical trials sorted by distance.

Page 1 of 45 (177 locations)

1

UCLA Hematology/Oncology - Santa Monica ( Site 0003)

Los Angeles, California, United States, 90404

2

Georgetown University Medical Center ( Site 0009)

Washington D.C., District of Columbia, United States, 20007

3

James Graham Brown Cancer Center ( Site 0017)

Louisville, Kentucky, United States, 40202

4

Johns Hopkins University ( Site 0052)

Baltimore, Maryland, United States, 21224