Status:
COMPLETED
Right Atrial Fibrosis in Pulmonary Hypertension
Lead Sponsor:
University of Giessen
Conditions:
Pulmonary Hypertension
Chronic Thromboembolic Pulmonary Hypertension
Eligibility:
All Genders
18+ years
Brief Summary
The study aim to assess right atrial (RA) remodeling, in terms of RA fibrosis, in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension patients. This will be investigated ...
Detailed Description
Right atrial (RA) function consists of a reservoir, conduit, and active contractile function and can serve as a tool for the evaluation of the severity of RV dysfunction and prognosis in pulmonary hyp...
Eligibility Criteria
Inclusion
- Confirmed diagnosis of pulmonary arterial hypertension, WHO group 1 or chronic thromboembolic pulmonary hypertension, group 4
- Invasive exclusion of pulmonary hypertension
- Age ≥ 18 years
- Signed informed consent
- planned right heart catheterization based on clinical grounds
Exclusion
- Other etiologic groups of pulmonary hypertension (WHO group 2, 3, 5)
- Patients with congenital heart disease
- Atrial septal defects
- Clinical relevant left heart disease
- Atrial fibrillation / Atrial flutter
- Ablations of the right atrium
- History of major cardiac surgery
- Atrial occlude
- Metallic implants
- Pacemakers
- Severe renal impairment (eGFR \< 30 ml/min)
- Other severe disease with a life expectancy below 12 month
- Pregnancy
- Any known factor or disease that might interfere with treatment compliance, study conduct, or interpretation of results
- Intolerance to a contrast agent containing gadolinium
- Inability to perform a cardiac magnetic resonance imaging (claustrophobia or similar)
Key Trial Info
Start Date :
April 30 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 30 2023
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04663230
Start Date
April 30 2021
End Date
November 30 2023
Last Update
May 17 2024
Active Locations (2)
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1
Kerckhoff-Klinik
Bad Nauheim, Hesse, Germany
2
University of Giessen
Giessen, Hesse, Germany, 35390