Status:
COMPLETED
Correlation Study of Corneal Nerve Changes and Dry Eye in Contact Lens Wearers
Lead Sponsor:
Peking University Third Hospital
Conditions:
Contact Lens Complication
Dry Eye
Eligibility:
All Genders
18-40 years
Brief Summary
This study aims to analyze the changes of corneal nerve morphology and function in contact lens-related dry eye(CLADE) patients and further discuss the role of corneal nerve in the genesis and develop...
Detailed Description
33 daily disposable soft contact lens wearers with dry eye disease(DED), 33 DED without contact lens wear and 33 normal control subjects will be involved in study. One experienced ophthalmologist will...
Eligibility Criteria
Inclusion
- Age 18years to 40 years；
- Male or female DED patients based on Chinese Dry Eye Diagnosis Standard (2020) with or without contact lens wear；
- Provision of written informed consent.
Exclusion
- Presence of any of the following conditions: active ocular infection, ocular inflammation, active ocular allergy, ocular surgical history, laser treatment in the last 3 months, Meibomian function (MGD) over grade 2 (the grade is according to the report of the International Workshop on MGD in 2011), severe blepharitis or obvious inflammation of the eyelid margin, which in the judgment of the investigator may interfere with the interpretation of the study results
- Pregnant and lactating women, or those planning a pregnancy over the course of the study
- Uncontrolled systemic disease
- Suffer from diseases that may affect corneal nerves, such as keratoconus, trigeminal neuralgia, allergic conjunctivitis, etc.
Key Trial Info
Start Date :
October 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2021
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04663529
Start Date
October 1 2020
End Date
October 1 2021
Last Update
June 1 2022
Active Locations (1)
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1
Peking University Third Hospital
Beijing, Beijing Municipality, China, 100191