Status:
COMPLETED
High-flow Oxygen Therapy vs Non-invasive Ventilation: Comparison of Alveolar Recruitment in Acute Respiratory Failure
Lead Sponsor:
University Hospital, Rouen
Conditions:
Acute Respiratory Failure With Hypoxia
Eligibility:
All Genders
18+ years
Brief Summary
This physiological study showed an increase in regional ventilation with NIV but no difference in alveolar recruitment as compared to HFNC in patients with hypoxemic ARF. Although NIV provided better ...
Detailed Description
Background: High-flow nasal cannula (HFNC) oxygen therapy has recently shown clinical benefits in hypoxemic acute respiratory failure (ARF) patients, while the interest of non-invasive ventilation (NI...
Eligibility Criteria
Inclusion
- Adult patients referred in ICU
- with hypoxemic acute respiratory failure due to a community acquired pneumonia confirmed by chest X ray,
- with PaO2 \< 60mmHg in ambient air, without hypercapnia (PaCO2 \< 45 mmHg),
- requiring more than 6L/min of O2 on admission with high concentration FM, and justifying HFNC or NIV for the attending ICU physician
Exclusion
- cardiogenic pulmonary oedema,
- moderate to severe underlying respiratory disease including COPD (chronic obstructive pulmonary disease)
- contraindication to or failure of previous NIV or HFNC with the need for immediate invasive ventilation
- pregnant or breast-feeding women
- carrier of an implantable defibrillator or pacemaker
- body mass index (BMI)\>50 kg/m2
- with cutaneous lesion next to the positioning zone of the Pulmovista® (Dräger, Lübeck, Germany) belt
Key Trial Info
Start Date :
February 22 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 19 2018
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT04664322
Start Date
February 22 2016
End Date
February 19 2018
Last Update
December 11 2020
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.