Status:
UNKNOWN
The Clinical Features of Combined Central and Peripheral Demyelination
Lead Sponsor:
Xuanwu Hospital, Beijing
Conditions:
Combined Central and Peripheral Demyelination Disease
Eligibility:
All Genders
Brief Summary
The investigators conduct this study to clarify the clinical features and to evaluate the prevalence of anti-nodal/paranodal antibodies of patients with combined central and peripheral demyelination (...
Detailed Description
The investigators will review the clinical manifestation, laboratory test results, electrophysiological examination and neuroimaging findings of patients with CCPD. And we will detect antibodies to aq...
Eligibility Criteria
Inclusion
- T2 high-signal intensity lesions in the brain or spinal cord on MRI, or visual-evoked potentials(VEPs) abnormalities.
- conduction delay, conduction block, temporal dispersion or F-wave abnormalities, suggesting peripheral demyelinating neuropathy regarding nerve conduction studies (NCS).
Exclusion
- infectious diseases(e.g., human T lymphocyte trophic virus type1-associated myelopathy, syphilis, neuroborreliosis, HIV infection or progressive multifocal leukoencephalopathy)
- pre-existing inflammatory diseases (e.g., sarcoidosis, Behçet's disease, Sjögren's syndrome, vasculitis or other collagen diseases)
- mitochondrial disease
- metabolic/toxic diseases (e.g., vitamin deficiency, amyloidosis, chronic alcoholism, diabetes mellitus or subacute myelo-opticoneuropathy due to clioquinol intoxication
- cervical spondylotic myelopathy
- syringomyelia
- spinocerebellar degeneration
- multiple myeloma, other tumors
- inherited diseases (e.g., leucodystrophies)
- cerebrovascular disease
- non-specific lesions on T2-weighted MRI (e.g., leucoaraiosis).
Key Trial Info
Start Date :
December 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2021
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04664647
Start Date
December 1 2020
End Date
January 1 2021
Last Update
December 16 2020
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.