Status:
COMPLETED
A Multicenter Study to Assess Response to Influenza Vaccine in Multiple Sclerosis Participants Treated With Ofatumumab
Lead Sponsor:
Novartis Pharmaceuticals
Conditions:
Relapsing Multiple Sclerosis
Eligibility:
All Genders
18-55 years
Phase:
PHASE4
Brief Summary
To assess whether participants treated with ofatumumab 20 mg subcutaneous (s.c.) administered once every 4 weeks (q4) can mount an adequate immune response to inactivated influenza vaccine as measured...
Detailed Description
Vaccinations against influenza are an important part of effective management of multiple sclerosis (MS). Ofatumumab is a human anti-CD20 monoclonal antibody (mAb) which depletes B-cells, a component ...
Eligibility Criteria
Inclusion
- Signed informed consent must be obtained prior to participation in the study
- Age 18-55 years old
- Diagnosis of relapsing MS by 2017 revised McDonald criteria
- Must be willing to comply with the study schedule
- Planning to receive a 2020-2021, 2021-2022, or 2022-2023 inactivated influenza vaccine
- Planning to start treatment with ofatumumab or already on commercially prescribed ofatumumab for at least 2 weeks prior to the screening visit
- Participants in Cohort 3 must fulfill criteria 1-5 above in addition to the following:
- Participant must currently be receiving iDMT
Exclusion
- Already has received the 2020-2021, 2021-2022, or 2022-2023 season influenza vaccine
- Known hypersensitivity to any component of the influenza vaccine
- Any safety finding including low IgG and/or low IgM levels requiring an ofatumumab treatment interruption within the 12 weeks immediately prior to Week 0
- Any major episode of infection requiring hospitalization or treatment with intravenous antibiotics within 4 weeks prior to or oral antibiotics within two weeks prior to Week 0
- Known clinical diagnosis of influenza infection during the 2020-2021 influenza season prior to starting the study based on investigator's or subject's personal physician's judgement (laboratory report of confirmed influenza infection is not required)
- Prior treatment with B-cell targeted therapies (e.g., rituximab or ocrelizumab), lymphocyte-trafficking blockers, alemtuzumab, anti-CD4, cladribine, cyclophosphamide, mitoxantrone, azathioprine, mycophenolate mofetil, cyclosporine, methotrexate, total body irradiation, bone marrow transplantation. Treatment with a natalizumab within 6 months of week 0
- Treatment with an S1P modulator within 60 days prior to Week 0
- Participants with any known active systemic bacterial, fungal or viral or fungal infections (such as hepatitis, progressive multifocal leukocencephalopathy, COVID-19 or HIV), or known to have acquired immunodeficiency syndrome (AIDS)
- Participation in another interventional clinical trial within 14 days prior to the screening visit
- Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test
- Women of child-bearing potential
- Patients with a history of Guillain-Barre syndrome within 6 weeks of receiving the influenza vaccination.
Key Trial Info
Start Date :
January 14 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 6 2023
Estimated Enrollment :
63 Patients enrolled
Trial Details
Trial ID
NCT04667117
Start Date
January 14 2021
End Date
July 6 2023
Last Update
October 9 2024
Active Locations (3)
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1
Hope Research Institute Center Neurology and Spine
Phoenix, Arizona, United States, 85018
2
Infinity Clinical Research LLC
Hollywood, Florida, United States, 33024
3
The MS Center for Innovation in Care
St Louis, Missouri, United States, 63131