Status:
COMPLETED
Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine
Lead Sponsor:
Aalborg University
Conditions:
Morphine
Histamine
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The aim of this study is to the effect of opioid (morphine) intradermal application on histaminergic and non-histaminergic itch. In particular, we would like to demonstrate that also peripheral admini...
Detailed Description
Opioids (i.e. substances extracted from opium poppies, e.g. morphine) are used for treatment of both acute and chronic pain conditions as well as in surgical procedures. Opioids render effective pain ...
Eligibility Criteria
Inclusion
- Healthy men and women
- 18-60 years
- Speak and understand English
Exclusion
- Participants with any clinically significant abnormalities that in the opinion of the investigator may increase the risk associated with trial participation or may interfere with the interpretation of the trial results.
- Pregnancy or lactation
- Drug addiction defined as any use of cannabis, opioids or other addictive drugs
- Lack of ability to cooperate
- Current use of medications that may affect the trial such as antihistamines, antipsychotics and pain killers as well as systemic or topical steroids.
- Participants with known allergy/discomfort to the opioid morphine and antihistamine.
- Skin diseases
- Moles, scars or tattoos in the area to be treated or tested.
- Consumption of alcohol or painkillers 24 hours before the study days and between these
- Acute or chronic pain
- Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)
Key Trial Info
Start Date :
July 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2022
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT04672382
Start Date
July 1 2021
End Date
December 31 2022
Last Update
January 18 2023
Active Locations (1)
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1
Silvia Lo Vecchio
Aalborg, North Denmark, Denmark, 9229