Status:
UNKNOWN
Prevalence of Occult Hepatitis B Virus Infection（OBI） in Subjects With Chronic Hepatitis B（CHB） Family History
Lead Sponsor:
First Affiliated Hospital Xi'an Jiaotong University
Conditions:
Chronic Hepatitis b
Eligibility:
All Genders
Brief Summary
Mother to Child transmission is the main route of hepatitis B virus (HBV) transmission in China, attributing to over 50% HBV infection. Familial aggregation in HBV infection is well recognized with un...
Detailed Description
Serum samples were tested for liver enzymes and liver synthesis function including ALT, aspartate aminotransferase（AST）, and albumin, etc. using a Hitachi 7600 automatic analyzer and reagent system (H...
Eligibility Criteria
Inclusion
- First- and second-degree relatives of CHB patients in west China；
- Subjects with family history of CHB related cirrhosis or HCC;
- Subjects with ability to understand and sign a written informed consent form.
Exclusion
- Positive antibody against hepatitis C virus(HCV),hepatitis D Virus(HDV), or human immunodeficiency virus(HIV) (anti-HCV, anti-HDV, or anti-HIV)
- Evidence of other autoimmune or metabolic liver diseases (except non-alcoholic fatty liver disease).
- Moribund state including advanced/pre-terminal liver cancer or other non-hepatic cancers
- Non-hepatic cancer undergoing chemotherapy within last 6 months
Key Trial Info
Start Date :
December 21 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2022
Estimated Enrollment :
2000 Patients enrolled
Trial Details
Trial ID
NCT04672915
Start Date
December 21 2020
End Date
December 30 2022
Last Update
March 31 2022
Active Locations (1)
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1
First Affiliated Hospital of Xi'an JiaotongUniversity
Xi'an, Shaanxi, China, 710061