Status:
COMPLETED
Vancomycin Tissue Concentrations by Bier Block or Intravenous Administration
Lead Sponsor:
Mayo Clinic
Conditions:
Infection
Hand Injury Wrist
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The purpose of this study is to determine whether or not giving a lower dose of antibiotics (Vancomycin) in the area where it is needed (upper extremity) is more effective at preventing infection than...
Eligibility Criteria
Inclusion
- Patients undergoing upper extremity reconstruction by a single surgeon.
- Surgical cases will include:
- Trapeziectomy/suspensionplasty.
- PIPJ/MPJ arthroplasty.
- Proximal row carpectomy.
- Distal ulnar resection.
- Distal radius fracture fixation.
Exclusion
- Inability to adequately cannulate a superficial vein in the upper extremity within 5 minutes of tourniquet inflation.
- Evidence of subcutaneous extravasation in Bier block group.
- History of renal dysfunction.
- Vancomycin allergy.
- ASA\>/= 3.
- History of lung cancer.
- Known HIV infection.
- History of organ transplantation.
Key Trial Info
Start Date :
August 26 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 17 2022
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04673877
Start Date
August 26 2021
End Date
August 17 2022
Last Update
October 7 2022
Active Locations (1)
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1
Mayo Clinic in Arizona
Phoenix, Arizona, United States, 85054