Status:
COMPLETED
A Prospective Study of Application of Platelet Mapping in Chronic Liver Disease Complicated With ALI and/or AD in China
Lead Sponsor:
Nanfang Hospital, Southern Medical University
Conditions:
Thrombelastography, Acute Liver Injury, Acute Decompensation, Platelet
Eligibility:
All Genders
18-80 years
Brief Summary
Ineffective hemostasis or a paradoxical prothrombotic state of Acute-on-chronic liver disease (ACLF) has been well established. Thrombelastography measures the dynamics of thrombin production and prov...
Eligibility Criteria
Inclusion
- chronic liver disease: including chronic liver hepatitis patients without cirrhosis, compensated cirrhosis patients, decompensated cirrhosis patients and non-alcoholic fatty liver disease patients.
- ALI(acute liver injury): including \[ALT \> 3 ULN(upper limited of normal),AST \> 3 ULN or TB \> 2 ULN within 1 week before enrollment\] or AD(acute decompensation) : including \[(having ascites, hepatic encephalopathy and/or bacterial infection within 1 month before enrollment)\].
Exclusion
- those who had hepatocellular carcinoma or other types of malignancies;
- obstructive biliary diseases or other disease lead to bilirubin evaluation;
- those who had acute hemorrhage one week before admission
- those who received platelet, cryo transfusion or plasmapheresis one week before admission
- pregnancy and breastfeeding
- those who received liver transplantation or kidney transplantation;
- combine with other disease lead to organ failure including heart failure (NYHA IV),respiratory failure（PaO2\<60mmHg),renal insufficiency(CKD 5) and conscious disturbance (GCS\<8)
- readmission;
- death within 24 hours.
Key Trial Info
Start Date :
July 6 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 5 2020
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04675125
Start Date
July 6 2020
End Date
December 5 2020
Last Update
December 19 2020
Active Locations (1)
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1
Nanfang Hospital
Guangzhou, Guangdong, China, 510515