Status:
UNKNOWN
A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous Polyposis
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Collaborating Sponsors:
Leiden University Medical Center
The Netherlands Cancer Institute
Conditions:
Familial Adenomatous Polyposis
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to determine the efficacy and safety of a personalized surveillance and intervention protocol for duodenal and gastric polyposis in patients with familial adenomatous poly...
Detailed Description
Patients with FAP are not only at risk of developing colorectal adenomas but also at high risk of developing duodenal adenomas. In 30% to 92% of FAP patients duodenal adenomas are detected, with a lif...
Eligibility Criteria
Inclusion
- Diagnosis of FAP, at least one of following: genetic diagnosis (proven APC germline mutation) and/or clinical diagnosis (\>100 colorectal adenomas in combination with a positive family history of FAP)
- Age 18 years or older
Exclusion
- Endoscopic removal of all polyps with an indication for removal not possible/feasible
- Gastric or duodenal cancer at baseline endoscopy
- Need for surgery
Key Trial Info
Start Date :
November 24 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2025
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT04677998
Start Date
November 24 2020
End Date
November 1 2025
Last Update
December 21 2020
Active Locations (1)
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1
Academic Medical Centre
Amsterdam, North Holland, Netherlands, 1105AZ