Status:
UNKNOWN
Transcriptomic Landscape of T Lymphocytes of Atopic Dermatitis, Atopic Prurigo Nodularis (of Besnier) and Non-atopic Prurigo Nodularis (of Hyde) Using Single Cell RNA-sequencing
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Prurigo Nodularis
Atopic Dermatitis
Eligibility:
All Genders
18+ years
Brief Summary
Prurigo nodularis (PN) is a skin condition characterized by symmetrically distributed widespread, pruritic nodules that occurs in patients with chronic pruritus. There are 2 subtypes of PN depending o...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- More than 18 years of age
- Signature of the written contentment
- Clinical diagnostic of PN defined by the following: a minimum of 20 PN lesions, in total on both legs, and/or both arms; an average worst itch score of ≥7. Atopic PN will be defined as PN associating clinical sings or history of AD according to Hanifin et Rajka criteria. Non-Atopic PN will be defined as PN non-associated with clinical sings or history of AD according to Hanifin et Rajka criteria.
- or confirmed diagnosis of AD according to Hanifin et Rajka criteria without associated PN.
- Washout period for topical treatments (\> 1 week) ans systemic treatments (\> 1 month).
- Indication and absence of contraindication to performing a skin biopsy as part of the treatment
- Inclusion criteria for healthy controls:
- more than 18 years of age
- Signature of the written contentment
- Hospitalised in the plastic surgery department of Saint-Louis Hospital.
- No associated inflammatory or tumoral skin condition
- No contraindication for biopsy
- Exclusion criteria :
- Presence of inflammatory or tumoral skin morbidities other than PN and atopic dermatitis
- Treatment induced pruritus
- Pruritus secondary to other medical conditions such as bullous dermatosis, renal insufficiency, infectious diseases, …)
- AD under biologic therapy
- Patient under guardianship or conservatorship
- No health insurance coverage
- Patient under State Medical Assistance (AME)
- Pregnancy or breastfeeding
- Persons deprived of their liberty by a judicial or administrative decision
- People undergoing psychiatric care making their consent impossible
- Adults who are the subject of a legal protection measure or unable to express their consent
- Patients unable to read and write
- Exclusion criteria for healthy controls:
- Inflammatory or tumoral medical condition
- Biological therapy for any other medical condition
- Associated inflammatory or tumoral skin condition
- Pregnancy or breastfeeding
- Persons deprived of their liberty by a judicial or administrative decision
- People undergoing psychiatric care making their consent impossible
- Adults who are the subject of a legal protection measure or unable to express their consent
- Patients unable to read and write
Exclusion
Key Trial Info
Start Date :
February 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 15 2021
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04681300
Start Date
February 1 2021
End Date
July 15 2021
Last Update
February 9 2021
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