Status:
UNKNOWN
A Trial of Procalcitonin in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Lead Sponsor:
Capital Medical University
Conditions:
Procalcitonin
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
40+ years
Phase:
PHASE3
Brief Summary
Current antibiotic prescription for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is generally based on the Anthonisen criteria in The Global Initiative for Chroni...
Detailed Description
This trial will recruit 500 hopitalized patients with AECOPD. The eligible participants will be randomly assigned to either PCT group or guideline group.The investigators aim to compare the efficacy a...
Eligibility Criteria
Inclusion
- Hospitalized patients with AECOPD
- ≥40 years of age
- Able to understand and communicate to ensure the completion of the trial
- Voluntary participation and provide written informed consent
Exclusion
- Fever, Axillary temperature≥38°C
- Pneumonia identified by X-Ray or CT of the chest
- Severe respiratory failure requiring admittance to ICU
- Concurrent infection at another site (e.g. urinary tract infection)
- Immunosuppression secondary to chemotherapy, AIDS or malignant tumor of blood system
- Comorbidities requiring corticosteroids (prednisone 30mg/d or equivalent more than 30 days )
- Invasive mechanical ventilation
- Patients with malignant tumors receiving chemotherapy or radiotherapy
- Pregnancy
- Participation in another clinical trial
- Previously enrollment into the study
- Refuse to attend
Key Trial Info
Start Date :
February 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2022
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT04682899
Start Date
February 1 2021
End Date
April 1 2022
Last Update
December 24 2020
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