Status:
WITHDRAWN
Liraglutide Plus Megestrol Acetate in Endometrial Atypical Hyperplasia
Lead Sponsor:
Xiaojun Chen
Collaborating Sponsors:
Huashan Hospital
Conditions:
Atypical Endometrial Hyperplasia
Obese
Eligibility:
FEMALE
18-45 years
Phase:
PHASE2
PHASE3
Brief Summary
To investigate the efficacy of liraglutide plus megestrol acetate in obesity patients with atypical endometrial hyperplasia (AEH)
Detailed Description
Backgrounds: High-dose progesterone (MA/MPA) or LNG-IUS is the first-line treatment for women with atypical endometrial hyperplasia (AEH) or early endometrioid cancer who want to preserve fertility. A...
Eligibility Criteria
Inclusion
- BMI (body mass index) ≥28kg/m2
- Consent informed and signed
- Pathologically confirmed as endometrial atypical hyperplasia
- Have a strong desire to reproduce and ask for fertility preservation or those who insist on keeping the uterus despite no reproductive requirements
- Have good compliance and follow-up conditions, and patients are willing to follow up in Obstetrics and Gynecology Hospital of Fudan University in time
Exclusion
- Diagnosed as type 2 diabetes
- Diabetic ketoacidosis
- History of acute pancreatitis
- Have a history or family history of medullary thyroid carcinoma; multiple endocrine neoplasia syndrome type 2 (MEN2)
- Combined with severe medical disease or severely impaired liver and kidney function
- Patients with other types of endometrial cancer or other malignant tumors of the reproductive system; patients with breast cancer or other hormone-dependent tumors that cannot be used with progesterone
- Those who require hysterectomy or other methods other than conservative treatment with drugs
- Deep vein thrombosis, stroke, myocardial infarction
- Smokers (≥15 cigarettes/day)
Key Trial Info
Start Date :
March 20 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 30 2026
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04683237
Start Date
March 20 2021
End Date
November 30 2026
Last Update
September 26 2024
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