Status:
UNKNOWN
The Neurocircuitry of Relief During Avoidance Learning in Patients With Obsessive-compulsive Disorder
Lead Sponsor:
KU Leuven
Conditions:
Obsessive-Compulsive Disorder
Eligibility:
All Genders
18-60 years
Brief Summary
To investigate the neuro-mechanisms underpinning persistent avoidance in OCD patients
Detailed Description
Many compulsions displayed by obsessive-compulsive disorder (OCD) patients serve to protect against perceived threat and can, therefore, be conceptualized as 'avoidance responses'. Exposure treatment ...
Eligibility Criteria
Inclusion
- Healthy volunteers 18-60 years old;
- Participants are motivated and give written informed consent;
- Adequate demand of Dutch language;
- Subjects have never participated in a fear conditioning task;
- Diagnosis of OCD (for OCD group only);
- Contraindications for the MRI exam.
Exclusion
- Current neurological (e.g. Epilepsia), respiratory, cardiovascular, metabolic, gastrointestinal, endocrine (especially diabetes), renal or urinary diseases, psychiatric disorder or other relevant medical histories (except for OCD in the OCD group);
- Being pregnant or lactating;
- Alcohol intake greater than 14 alcoholic units per week (one alcoholic unit = 10 gr ethanol);
- History of cannabis use or any other drug of abuse during the 3 months prior to the study;
- The medical doctor has asked to the participant to stay away from stressful situations;
- Electronic implants (e.g., pacemaker);
- Pain or other condition of the hand or the wrist.
Key Trial Info
Start Date :
January 10 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2022
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04685018
Start Date
January 10 2020
End Date
May 1 2022
Last Update
December 28 2020
Active Locations (1)
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1
Psychiatry | UZ Leuven campus Gasthuisberg
Leuven, Belgium, 3000