Status:
ACTIVE_NOT_RECRUITING
Doxycycline for Elbow Tendinopathy
Lead Sponsor:
Hospital for Special Surgery, New York
Conditions:
Lateral Epicondylitis
Lateral Epicondylitis, Left Elbow
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
To evaluate the feasibility of subantimicrobial -dose (SD) doxycycline to improve outcomes of nonsurgical management of elbow tendinopathy via matrix metalloproteinase (MMP) inhibition as well as eval...
Detailed Description
: elbow tendinopathy is a common condition among athletes and the general population. It can result in significant disability and time loss from work. Despite traditional nonsurgical treatment, sympto...
Eligibility Criteria
Inclusion
- Males and females ages of 18 and up
- Atraumatic unilateral elbow pain of ≥ 6 weeks duration
- Diagnosed clinically as lateral or medial elbow tendinopathy
- Activity-related lateral or medial elbow pain
- Tenderness of the lateral or medial epicondyle
- Pain with gripping and/or resisted wrist extension with the elbow extended
- Pain with passive wrist flexion and finger with the elbow extended
- Internet access to complete electronic surveys
Exclusion
- Prior surgery of the affected elbow
- Prior injection of the affected lateral or medial epicondyle or extensor tendons
- Prior extracorporeal shockwave therapy to the affected elbow
- Suspicion for radial tunnel syndrome (tenderness distal to the lateral epicondyle in the area of the supinator muscle dorsally, pain with resisted supination with the elbow extended, and/or weakness of the extensor digitorum communis)
- Separate upper extremity injury or condition that would interfere with full participation in the home exercise program
- Fluoroquinolone-associated tendinopathy
- Ligamentous laxity on exam
- Evidence of osteoarthritis or osteochondral lesion on radiographs
- Autoimmune condition
- Pregnant, intend to become pregnant, or breastfeeding
- Premenopausal women who are not using contraception
- Allergy to doxycycline or other tetracyclines
- Current esophagitis or peptic ulcer disease
- Current use of medication for which there is a drug interaction with doxycycline
- Who do not speak English
Key Trial Info
Start Date :
December 3 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2026
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT04686799
Start Date
December 3 2020
End Date
January 1 2026
Last Update
December 16 2025
Active Locations (1)
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1
Hospital for Special Surgery
New York, New York, United States, 10021