Status:
UNKNOWN
Gut Microbiota and Serum Markers for Cognitive Impairment and Poor Prognosis After Ischemic Stroke
Lead Sponsor:
Nanfang Hospital, Southern Medical University
Collaborating Sponsors:
Guangdong 999 Brain Hospital
Zhujiang Hospital
Conditions:
Ischemic Stroke
Eligibility:
All Genders
18-75 years
Brief Summary
Post-stroke cognitive impairment(PSCI) is one of the most important factors causing disabilities after stroke. Recent study found that gut microbiota plays a key role in neurological diseases. Two rec...
Eligibility Criteria
Inclusion
- Meet the diagnostic criteria for acute ischemic stroke;
- Aged between 18-75;
- Onset within 7 days;
- Sign informed consent and agree to provide relevant medical history data and biological specimens.
Exclusion
- Patients diagnosed with TIA
- Severe disturbance of consciousness (NIHSS consciousness score \> 1)
- Previous severe mental disorders and dementia (AD8 score ≥ 2)
- History of cerebral hemorrhage or any stroke within 12 months;
- Serious systemic diseases including malignant tumors
- Patients with aphasia and unable to cooperate to complete the Montreal Cognitive Assessment (MoCA)
- ALT or AST greater than 2 times the upper limit of normal value or severe liver disease;
- GFR less than 30mL/min/1.72m2 or severe kidney disease
- Alcohol abused, drug use and chemical poisoning history (such as pesticide poisoning)
- Patients with previous history of gastrointestinal tract or confirmed during hospitalization
- Patients who could not collect stool samples within 4 days after admission.
Key Trial Info
Start Date :
June 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2023
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT04688138
Start Date
June 1 2020
End Date
June 30 2023
Last Update
August 2 2021
Active Locations (1)
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1
Department of Neurology, NanFang Hospital, Southern Medical University
Guanzhou, Guangdong, China, 510515