Status:
COMPLETED
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Methotrexate vs Hydroxychloroquine
Lead Sponsor:
Brigham and Women's Hospital
Collaborating Sponsors:
National Institute on Aging (NIA)
Rutgers University
Conditions:
Rheumatoid Arthritis
Eligibility:
All Genders
18+ years
Brief Summary
This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alter...
Detailed Description
This is a non-randomized, non-interventional study that is part of the DREAM Study of Brigham and Women's Hospital. DREAM is led by Dr. Madhav Thambisetty, MD, PhD, Chief of the Clinical and Translati...
Eligibility Criteria
Inclusion
- Please see https://docs.google.com/spreadsheets/d/14HJn7W3NfPFcaowVDniCi9ulLRKRN2fn2jyeJjGgtzc/edit?usp=sharing or Appendix A for full code and algorithm definitions.
- Medicare timeframe: 2007 to 2017 (end of data availability).
- 1\. No prior use of methotrexate or hydroxychloroquine anytime prior to cohort entry date
- 2\. Enrollment in Medicare Part A, B, and D with no HMO coverage for 365 days prior to and including cohort entry date
Exclusion
- 1\. Prior history of dementia measured anytime prior to cohort entry date
- 2\. No prior history of rheumatoid arthritis recorded in the 365 days prior to cohort entry date
- 3\. Prior history of nursing home admission in the 365 days prior to the cohort entry date
- 4\. Prior history of DMARD use measured anytime prior to cohort entry date
Key Trial Info
Start Date :
December 23 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 31 2021
Estimated Enrollment :
133553 Patients enrolled
Trial Details
Trial ID
NCT04691505
Start Date
December 23 2020
End Date
August 31 2021
Last Update
November 23 2021
Active Locations (1)
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1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02120