Status:
COMPLETED
Study on the Mechanism of Regulating Gut Microbiome in Obese People by Regulating Brain-gut Axis With Fast Diet
Lead Sponsor:
Henan Provincial People's Hospital
Conditions:
Obesity
Gastrointestinal Microbiome
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
1. Normal diet：Starting from May 20, 2018, the subjects will eat a normal diet for 4 days, with no restriction on calories and food types. The subjects are required to record their daily diet and diet...
Detailed Description
1. Normal diet: the course of treatment was 4 days. The subjects were asked to record the daily diet and dietary intake in the daily observation scale (Table 1). 2. High control diet intervention: the...
Eligibility Criteria
Inclusion
- BMI greater than or equal to 28 kg/m2, waist circumference greater than or equal to 90cm for men and 85cm for women.
- Aged between 18 and 60.
- Patients may be accompanied by diseases such as abnormal blood pressure, abnormal blood lipid, abnormal uric acid, metabolic syndrome, respiratory sleep, constipation, etc., but they can only participate in these diseases if there is no obvious risk after clinical evaluation.
- No serious heart, brain, liver and kidney dysfunction, uremia coma, ketoacidosis, hypoglycemia, anemia, malnutrition, hematopoietic system and body immune system diseases, infectious diseases, neurological diseases.
- 5, the body does not contain the implantation or other metal materials such as the implantable metal denture, cardiac pacemaker, artificial joint, insulin pump and so on, no claustrophobia, non-pregnancy, suitable for magnetic resonance examination to participate in.
Exclusion
- those who do not meet the above diagnostic criteria have poor compliance and have not signed a voluntary informed consent to participate in the experimental study.
- patients with severe cardiac, cerebral, hepatic and renal dysfunction, uremia coma, ketoacidosis, hypoglycemia, anemia, malnutrition, hematopoietic system and physical immune system diseases, infectious diseases, neurological diseases, etc.
- special groups such as female menstruation, minors, pregnant women, and the elderly over 60 years old.
Key Trial Info
Start Date :
April 11 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2018
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT04691583
Start Date
April 11 2018
End Date
July 31 2018
Last Update
December 31 2020
Active Locations (1)
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1
Henan Provincial People's Hospital
Zhengzhou, Henan, China