Status:
NOT_YET_RECRUITING
Prognostication of Recovery in Early Disorders of Consciousness Study
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Disorders of Consciousness Due to Severe Brain Injury
Eligibility:
All Genders
18+ years
Brief Summary
By collecting multimodal metrics (e.g., clinical factors, neuroimaging, and EEG) in the early phase of severe brain injury (i.e., during the acute hospitalization when a patient has impaired conscious...
Detailed Description
The primary aim of this research proposal is as follows: By collecting multimodal metrics (e.g., clinical factors, neuroimaging, and EEG) in the early phase of severe brain injury (i.e., during the ac...
Eligibility Criteria
Inclusion
- Acute brain injury (including ischemic stroke, intracranial hemorrhage, anoxic brain injury, traumatic brain injury, encephalitis)
- Inability to follow commands, speak intelligibly, or communicate (i.e., diagnosis of coma, vegetative state, or minimally conscious state minus) due to the underlying brain injury and within 28 days of the brain injury
- Age 18 or greater.
Exclusion
- Subjects will be excluded if they do not speak English (given the reliance on verbal questionnaires conducted in English) or if they regain the ability to follow commands, speak intelligibly or communicate (i.e., improves to minimally conscious state plus or greater) before they undergo MRI or EEG.
Key Trial Info
Start Date :
August 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 30 2026
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04692922
Start Date
August 1 2025
End Date
July 30 2026
Last Update
August 21 2024
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