Status:
COMPLETED
Early Luteal Hormones and IVF Outcomes After hCG Triggering
Lead Sponsor:
Mỹ Đức Hospital
Conditions:
Luteal Phase
in Vitro Fertilisation
Eligibility:
FEMALE
18-38 years
Brief Summary
It has recently been demonstrated that a bolus trigger of hCG induces various unphysiological conditions in the early luteal phase that may negatively affect an IVF treatment cycle's reproductive outc...
Detailed Description
The early luteal phase after ovarian stimulation and final oocyte maturation using a bolus trigger of hCG is an area that has not received the same attention as regimes and protocols for ovarian stimu...
Eligibility Criteria
Inclusion
- Age 18 - 38
- BMI \< 28kg/m2
- Normal ovarian reserve (anti-Müllerian hormone level above 8.93 pmol/L or an antral follicle count of 6 or above within two months prior to stimulation)
- Having 4 to 19 follicles with a diameter of 14mm or above on the day of hCG triggering
- Receiving a standard GnRH-antagonist protocol for ovarian stimulation
- Having indication for fresh embryo transfer
- Willingness to participate in the study, and to disclose any medical conditions to the investigator. The patient must be prepared and willing to comply with the requirements of the protocol.
- The patient should after appropriate oral and written consent understand the study and be informed that she may withdraw consent at any time without prejudice to future medical care.
Exclusion
- Previous poor ovarian response (≤ 3 follicles) after appropriate FSH stimulation
- Hyper-response defined as ≥20 follicles ≥14 mm on the day of trigger
- Chronical medical conditions like Diabetes, Crohns disease, Thyroid disease, Hepatitis B, Sexually Transmitted Diseases and simultaneous participation in an interventional clinical trial.
Key Trial Info
Start Date :
January 12 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 31 2023
Estimated Enrollment :
95 Patients enrolled
Trial Details
Trial ID
NCT04693624
Start Date
January 12 2021
End Date
January 31 2023
Last Update
July 5 2023
Active Locations (1)
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1
Mỹ Đức Hospital
Ho Chi Minh City, Tan Binh, Vietnam