Status:
UNKNOWN
A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Lymphoma
Lead Sponsor:
First Affiliated Hospital of Zhejiang University
Collaborating Sponsors:
Shanghai AbelZeta Ltd.
Conditions:
Non-Hodgkin's B-cell Lymphoma
Eligibility:
All Genders
18-70 years
Phase:
PHASE1
Brief Summary
This is a single-arm, open label, dose escalation, phase I study of C-CAR039 in adults with relapsed/refractory B-cell Non-Hodgkin's Lymphoma.
Detailed Description
This is a single-arm, open label, "3+3" dose escalation, phase I study to evaluate the safety and preliminary efficacy of C-CAR039 in adults with relapsed/refractory B-cell Non-Hodgkin's Lymphoma. 10 ...
Eligibility Criteria
Inclusion
- The patient volunteered to participate in the study and signed the Informed Consent;
- Age between 18 and 70 (including 18 and 70), male or female;
- Expected survival ≥ 12 weeks;
- ECOG score 0-2
- CD19 or CD20 positive B-NHL confirmed by cytology or histology according to WHO2016 criteria, including DLBCL, PMBCL, tFL, FL and MCL;
- Relapsed or refractory disease after ≥ 2 lines (for FL, at least 3 lines) of standard therapy or relapsed after autologous stem cell transplantation (ASCT)
- For CD20-positive subjects, they should have received at least one regimen containing anti-CD20-targeted therapy (such as rituximab). If they do not complete the regimen due to intolerance, the cause of intolerance should be recorded;
- No contraindications of apheresis;
- At least one measurable lesion according to Lugano 2014 criteria;
- Adequate organ function.
Exclusion
- Malignant tumors other than B-NHL within 5 years prior to screening, except cervical carcinoma in situ, basal cell or squamous cell skin cancer, local prostate cancer after radical surgery, and breast ductal carcinoma in situ after radical surgery;
- Active HIV, HBV, HCV or treponema pallidum infection ;
- Any instability of systemic disease, including but not limited to active infection (except local infection), severe cardiac, liver, kidney, or metabolic disease need therapy;
- Any uncontrolled, active disease that prevents participation in the trial;
- Female subjects who have been pregnant or breastfeeding, or who plan to conceive during or within 1 year after treatment, or male subjects' partner plans to conceive within 1 year after their cell transfusion;
- Active or uncontrolled infections requiring systemic treatment within 14 days before enrollment;
- Patients who have been previously infected with tuberculosis;
- Administered Corticosteroids and/or other immunosuppressants within 7 days before apheresis. and 5 days before the infusion of C-CAR039;
- Patients with central nervous system involvement;
- Any systemic antitumor therapy was performed within 2 weeks before conditional treatment chemotherapy pretreatment;
- Any situation that the investigator believes would compromise the safety of the subject or interfere with the purpose of the study;
- Those with medical conditions that prevent them from signing the written informed consent or from complying with the study procedures; or those who are unwilling or unable to comply with the study requirements.
- Other conditions deemed unsuitable for enrollment by the investigator.
Key Trial Info
Start Date :
August 3 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 30 2024
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT04693676
Start Date
August 3 2020
End Date
April 30 2024
Last Update
September 28 2023
Active Locations (1)
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1
The First Affiliated Hospital, College of Medicine, Zhejiang University
Hangzhou, Zhejiang, China, 310003