Status:
UNKNOWN
Repetitive Transcranial Magnetic Stimulation on Freezing of Gait in People With Parkinson's Disease
Lead Sponsor:
Taipei Medical University Shuang Ho Hospital
Conditions:
Gait Disorders, Neurologic
Eligibility:
All Genders
45-80 years
Phase:
NA
Brief Summary
Parkinson's disease (PD) is the second most common neurodegenerative disease. The cardinal symptoms of PD are tremor, rigidity, bradykinesia and postural instability. Gait disturbance is also one of t...
Detailed Description
The present trial is designed as an open-label, uncontrolled pilot study for evaluating the effect of rTMS on improvement of freezing of gait (FOG) in people with PD. The primary endpoint is the impro...
Eligibility Criteria
Inclusion
- Fulfill the Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's disease, age between 45-80 years old.
- Can walk independently for 10 meters
- With FOG at either on or off period of time
Exclusion
- \- People with
- pre-existing and active major neurological diseases other than PD
- with a previous history of seizures
- with implanted metallic objects that would contraindicate rTMS
- unable to perform fMRI
- with skin damage on the stimulation area
- with multiple sclerosis
- with large ischemic scars
- with a family history or medical history of seizures, epilepsy
- brain damage may affect the threshold for inducing epilepsy
- taken tricyclic antidepressants, analgesics, or anything that may lower the threshold for inducing epilepsy
- with sleep disorders during the rTMS treatment
- with severe alcohol abuse or use of epilepsy drugs
- with severe heart disease or uncontrollable migraine caused by high intracranial pressure
- who are actively suicidal during the trial period, have recurring major medical disorders, or with neurological co-morbidities such as space occupying lesions, CVA, aneurysms etc
Key Trial Info
Start Date :
January 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2023
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04695496
Start Date
January 1 2021
End Date
March 31 2023
Last Update
April 5 2021
Active Locations (1)
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1
Shuang Ho Hospital
New Taipei City, Taiwan