Status:
COMPLETED
Physiopathology, Diagnosis and Therapy of Primary Cephalalgia and Adaptive Disorders
Lead Sponsor:
IRCCS National Neurological Institute "C. Mondino" Foundation
Conditions:
Migraine
Eligibility:
All Genders
18-60 years
Brief Summary
The main aim of the present pilot study is to prove the possibility to use the Nitroglycerin (NTG) model to describe the pathophysiology of headache using task-free advanced Magnetic Resonance Imaging...
Detailed Description
Resting state functional magnetic resonance imaging (rs-fMRI) has depicted cyclical functional connectivity changes during the ictal and inter-ictal phase of the migraine attack. In this pilot study, ...
Eligibility Criteria
Inclusion
- Episodic migraineurs
- age between 18-60 years;
- diagnosis of episodic migraine without aura developed before the age of 50;
- no current prophylactic treatment for migraine prevention;
- chronic migraineurs with medication overuse according to the ICHDIII criteria
Exclusion
- chronic or medication-overuse headache or cluster headache diagnosis;
- any chronic pain condition or disorders other than migraine;
- an alleged diagnosis of major psychiatric disorders such as depression, bipolar affective disorder and schizophrenia;
- a diagnosis of tension type headache with a frequency of more than 5 days per month;
- any cardiovascular diseases in which the NTG use could be contraindicated;
- blood pressure hypotension, closed angle glaucoma, anaemia;
- women in child bearing, breast feeding; continuous use of benzodiazepines;
- any neuroradiological pathological findings at a previous MRI scan of the head.
- Chronic migraineurs
- Inclusion Criteria:
- age between 18-60 years;
- diagnosis of migraine without aura developed before the age of 50 according to the ICHD III criteria;
- currently chronic migraineurs with medication overuse according to The International Classification of Headache Disorders 3rd edition (ICHDIII) criteria.
Key Trial Info
Start Date :
August 31 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 15 2020
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT04696510
Start Date
August 31 2018
End Date
December 15 2020
Last Update
January 6 2021
Active Locations (1)
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1
Headache Science Center
Pavia, Italy, 27100