Status:
RECRUITING
Protective Effect of Statin Against Negative Cardiovascular Remodeling and Organ Dysfunction After Acute Aortic Syndrome Surgery (PANDA III)
Lead Sponsor:
Nanjing Medical University
Collaborating Sponsors:
Beijing Anzhen Hospital
West China Hospital
Conditions:
Acute Aortic Syndrome
Aortopathy
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Acute Aortic Syndrome (AAS)/Aortic Aneurysm is a common feature of aortic wall events, including aortic dissection, intramural hematoma, aortic ulceration and aortic trauma, and occurs in up to 35 cas...
Eligibility Criteria
Inclusion
- (1) Patients with aortic dissection/ulceration/intermural hematoma/aortic aneurysm who underwent aortic arch replacement or endoluminal isolation or hybrid therapy;
- (2) Paitents without clinically significant hyperlipidemia but with cardiovascular disease risk factors (such as male ≥45 years old, female ≥55 years old, hypertension, diabetes, chronic kidney disease, obesity, low HDL cholesterol, smoking, alcohol consumption, family history of early onset ischemic cardiovascular disease) and no previous use of statins;
- (3) Patients are between 18 and 85 years old, male or female;
- (4) Agree to participate in the study and sign the informed consent.
Exclusion
- (1) Patients with allergy to statins;
- (2) patients with active liver disease;
- (3) patients with myopathy;
- (4) Lactating women and pregnant women;
- (5) Patients with mental diseases, drug and alcohol dependence;
- (6) Refuse to participate in the study or sign the informed consent.
Key Trial Info
Start Date :
January 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT04699279
Start Date
January 1 2021
End Date
December 31 2024
Last Update
December 13 2024
Active Locations (5)
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1
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China
2
The first affiliated hospital of nanjing medical university
Nanjing, Jiangsu, China, 210029
3
Affiliated Hospital of Qingdao University
Qingdao, Shandong, China
4
West China Hospital of Sichuan University
Chengdu, Sichuan, China