Status:
COMPLETED
Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine (Second Sub-Project)
Lead Sponsor:
Aalborg University
Conditions:
Itch
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The aim of our 2nd sub-project is to clarify if the capsaicin receptor TRPV1 is implicated in the mechanism of morphine-induced mast cell degranulation. Moreover, we also aim to clarify if the mechani...
Eligibility Criteria
Inclusion
- Healthy men and women
- 18-60 years
- Speak and understand English
Exclusion
- Participants with any clinically significant abnormalities that in the opinion of the investigator may increase the risk associated with trial participation or may interfere with the interpretation of the trial results.
- Pregnancy or lactation
- Drug addiction defined as any use of cannabis, opioids or other addictive drugs
- Lack of ability to cooperate
- Current use of medications that may affect the trial such as antihistamines, antipsychotics and pain killers as well as systemic or topical steroids.
- Participants with known allergy/discomfort to the opioid morphine and antihistamine.
- Skin diseases
- Moles, scars or tattoos in the area to be treated or tested.
- Consumption of alcohol or painkillers 24 hours before the study days and between these
- Acute or chronic pain
- Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)
Key Trial Info
Start Date :
January 18 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2021
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT04700007
Start Date
January 18 2021
End Date
December 31 2021
Last Update
January 27 2022
Active Locations (1)
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1
Mech-Sense, Medicinsk Gastroenterologisk ambulatorium, Medicineshus, Aalborn Universitethospitalet
Aalborg, North Denmark, Denmark, 9000