Status:
COMPLETED
Synuclein-One Study
Lead Sponsor:
CND Life Sciences
Conditions:
Parkinson Disease
Multiple System Atrophy
Eligibility:
All Genders
40-99 years
Brief Summary
The Synuclein-One Study will be evaluating α-synuclein in patients with Parkinson's disease, Multiple System Atrophy, Dementia with Lewy bodies and Pure Autonomic Failure. Using a simple diagnostic te...
Detailed Description
Phosphorylated α-synuclein pathology in the diagnosis of synucleinopathies through qualitative and quantitative measurements of cutaneous phosphorylated α-synuclein in patients with Parkinson's diseas...
Eligibility Criteria
Inclusion
- Male and female between 40-99 years of age
- Prior clinical diagnosis of Parkinson's disease, Multiple System Atrophy, Dementia with Lewy bodies or Pure Autonomic Failure
- Health Subjects, no history of clinical or symptoms suggestive with synucleinopathy
Exclusion
- Clinical evidence of severe vascular disease (history of ulceration, poor wound healing, vascular claudication)
- Clinically active coronary artery or cerebrovascular disease
- Current smoker or alcoholism
- History of allergic reaction to local anesthesia for skin biopsies
- Use of blood thinners (aspirin or Plavix alone is allowed)
- Significantly impaired wound healing or history of scarring or keloid formation
- Healthy individuals or individuals with synucleinopathy is disease may be explained by other causes: recent history of encephalitis, Cortical dementia of Alzheimer's type, Whipple's disease, toxin exposure, repeated head injury and stepwise disease progression suggestive of vascular etiology
Key Trial Info
Start Date :
January 4 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 8 2023
Estimated Enrollment :
428 Patients enrolled
Trial Details
Trial ID
NCT04700722
Start Date
January 4 2021
End Date
November 8 2023
Last Update
January 3 2024
Active Locations (23)
Enter a location and click search to find clinical trials sorted by distance.
1
MD First Research
Chandler, Arizona, United States, 85286
2
CND Life Sciences
Phoenix, Arizona, United States, 85018
3
Movement Disorders Center of Arizona
Scottsdale, Arizona, United States, 85258
4
The Neuro Center
Carlsbad, California, United States, 92011