Status:
COMPLETED
Regulation of Muscle Protein Phenotype in Humans With Obesity
Lead Sponsor:
Mayo Clinic
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Obesity
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
A hallmark of muscle changes in obesity is an altered muscle fiber type profile, characterized by a reduced proportion of Type I fibers - a shift associated with adverse obesity-related health outcome...
Detailed Description
Humans with obesity have typically lower proportion of Type I muscle fibers in skeletal muscle. These fiber types, known for their high capacity for glucose uptake, have also greater sensitivity to fu...
Eligibility Criteria
Inclusion
- ability to sign informed consent form
- body mass index (BMI), 18-26 kg/m2 (lean subjects), 32-50 kg/m2 (subjects with obesity)
Exclusion
- prescription or over-the-counter medication
- supplements known to affect protein metabolism (i.e., amino acids, protein, omega-3 fatty acids)
- diabetes
- acute illness
- liver disease
- uncontrolled metabolic disease, including renal disease
- heart disease related to atrial fibrillation, history of syncope, limiting or unstable angina, congestive heart failure or ECG documented abnormalities
- low hemoglobin or hematocrit
- use of anabolic steroids or corticosteroids (within 3 months)
- not classified as inactive/sedentary based on the Stanford Brief Activity Survey and accelerometry data
- participation in a weight-loss regimen
- extreme dietary practices (i.e., vegan, vegetarian)
- smoking
- pregnancy
- gastro-intestinal surgery
- any other condition or event considered exclusionary by the PI and the study physician.
Key Trial Info
Start Date :
October 7 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 2 2024
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT04700800
Start Date
October 7 2021
End Date
October 2 2024
Last Update
November 5 2025
Active Locations (1)
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1
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259