Status:
COMPLETED
Plaque Erosion Prospective Study ii
Lead Sponsor:
Norfolk and Norwich University Hospitals NHS Foundation Trust
Conditions:
Atheroma; Myocardial
Eligibility:
All Genders
18-75 years
Brief Summary
Plaque erosion is associated with myocardial infarction (MI) in about 30% of cases and may require a different management approach to plaque rupture. The investigators hypothesise that plaque erosion ...
Detailed Description
This is a prospective observational pilot study to assess the feasibility of studying endothelial cell and neutrophil differences between coronary atherosclerotic plaque rupture and plaque erosion in ...
Eligibility Criteria
Inclusion
- Provision of written informed consent, \< 75 years old
- NSTEMI group: Admission to hospital within 24 hr of pain onset. Scheduled to undergo invasive angiography ± PCI during index admission
- Stable angina group: Scheduled to undergo elective PCI
Exclusion
- Cardiogenic shock or haemodynamic instability,
- NSTEMI due to stent thrombosis restenosis, coronary dissection or embolism
- Previous CABG
- Requirement for mechanical ventilation
- Known severe renal impairment (eGFR \<45 ml/min/1.73m2)
- Known haematological malignancy or systemic inflammatory disorder
- Requirement for emergency cardiac surgery
- Inability to carry out OCT
Key Trial Info
Start Date :
October 15 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 31 2023
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT04701385
Start Date
October 15 2020
End Date
January 31 2023
Last Update
December 18 2023
Active Locations (1)
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1
Norfolk and Norwich University Hospitals NHS Foundation Trust
Norwich, Norfolk, United Kingdom, NR4 7UY