Status:
UNKNOWN
Investigation of Brain Plasticity in Autism Spectrum Disorders
Lead Sponsor:
Boston Children's Hospital
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Simons Foundation Autism Research Initiative (SFARI)
Conditions:
Autism Spectrum Disorder
Eligibility:
All Genders
6-18 years
Brief Summary
Individuals with autism spectrum disorders (ASD) commonly experience variances in tactile behaviors, such as hypersensitivity to light touch stimuli, altered texture discrimination, and hyporesponsivi...
Detailed Description
Individuals with autism spectrum disorders (ASD) commonly experience variances in tactile behaviors, such as hypersensitivity to light touch stimuli, altered texture discrimination and hyporesponsivit...
Eligibility Criteria
Inclusion
- For ASD group:
- Clinical diagnosis of a disorder on the autism spectrum according to:
- DSM-IV or DSM 5 criteria
- IQ\>70 (as determined by the Abbreviated Stanford-Binet IQ)
- For the Control group:
- No history of ASD or other developmental delay
- No history of ASD or other developmental delay in first-degree relatives.
- No history of clinical diagnosis of an anxiety disorder
Exclusion
- Both ASD and Control groups:
- Intracranial pathology, cerebral palsy, history of severe head injury, or syndromic dysmorphology
- History of fainting spells of unknown or undetermined etiology that might constitute seizure
- History of seizure or epilepsy
- Chronic (particularly) uncontrolled medical conditions that may cause a medical emergency
- Metal implants (excluding dental fillings) or devices such as pacemaker, medication pump, nerve stimulator, TENS unit, ventriculo-peritoneal shunt unless cleared by the responsible MD
- Substance abuse or dependence within the past six months
- Chronic treatment with prescription medications that decrease cortical seizure threshold
- Peripheral neuropathy, as determined by the study MD during neurologic exam
- For the Control group:
- For control participants' medical history will be reviewed for diagnoses of neurologic or psychiatric disease. If in the judgment of the investigator, the condition, e.g., depression, is well-controlled with stable medications, and does not include abnormalities of the sensory motor systems, they may be included in the study. Control participants will be excluded from taking part in the study if they have a 1st degree relative with ASD.
Key Trial Info
Start Date :
June 10 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2022
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04706364
Start Date
June 10 2019
End Date
May 1 2022
Last Update
November 5 2021
Active Locations (1)
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1
Boston Children's Hospital
Boston, Massachusetts, United States, 02115