Status:
COMPLETED
Extubation Advisor: Initial Implementation and Evaluation of a Novel Extubation Clinical Decision Support Tool
Lead Sponsor:
Ottawa Hospital Research Institute
Conditions:
Airway Extubation
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Expeditious, safe extubation is vitally important in the care of Intensive Care Unit (ICU) patients, as prolonged mechanical ventilation harms patients and failed extubation (i.e. re-intubation within...
Eligibility Criteria
Inclusion
- In the Intensive Care Unit (ICU)
- Able to provide informed consent (through a surrogate)
- Invasive mechanical ventilation for \> 48 hours
- Ready for spontaneous breathing test (SBT) for assessment for extubation
- At least partial reversal of the condition precipitating mechanical ventilation
- Stabilization of other organ systems
- Toleration of pressure support ventilation less than or equal to 14 cm H2O, (oxygen saturation (SpO2) greater than or equal to 90% with fraction of inspired oxygen (FiO2) less than or equal to 40% and positive end-expiry pressure (PEEP) less than or equal to 10cm H2O)
- Hemodynamic stability (low - phenylephrine less than 50 ug/min; norepinephrine less than 5 ug/min; dobutamine less than 5 ug/kg/min; milrinone less than 0.4 ug/kg/min - or no vasopressors)
- Stable neurological status (no deterioration in Glasgow coma score during prior 24 hours and, if measured, intracranial pressure (ICP) less than 20 mmHg)
- Intact airway reflexes (adequate cough with suctioning and a gag reflex)
- Normal sinus rhythm at the time of the SBT (no pacemaker)
Exclusion
- Order not to re-intubate should the patient fail extubation
- Anticipated withdrawal of life support
- Known or suspected severe weakness (myopathy, neuropathy, or quadriplegia)
- Tracheostomy
- Prior extubation during current ICU stay
Key Trial Info
Start Date :
October 4 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 13 2023
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT04708509
Start Date
October 4 2021
End Date
January 13 2023
Last Update
May 15 2025
Active Locations (1)
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1
The Ottawa Hospital, General Campus
Ottawa, Ontario, Canada, K1H 8L6