Status:
ENROLLING_BY_INVITATION
Adaptive Immune Response in Visceral and Subcutaneous Fat: Role in Human Insulin Resistance
Lead Sponsor:
Stanford University
Collaborating Sponsors:
American Heart Association
Conditions:
Insulin Resistance
Insulin Sensitivity
Eligibility:
All Genders
30-65 years
Brief Summary
The proposed study is designed to test the hypothesis that in human obesity, the balance of pro- and anti-inflammatory T cells in fat tissue is in fact related to macrophage phenotype and insulin resi...
Detailed Description
Previous studies have found convincing evidence of the relationship between insulin resistance, T cell profiles, macrophage profiles and inflammation of the fat cells. This study will add human subjec...
Eligibility Criteria
Inclusion
- Current patients of Stanford Healthcare, Bariatric Surgery Clinic, scheduled to undergo bariatric surgery (sleeve or RYGB)
- BMI 30-55kg/m2
- 30-65 years of age
- good general health, no major organ disease
- non-diabetic by current American Diabetes Association (ADA) criteria (fasting glucose \<126mg/dl)
Exclusion
- Subjects with any clinical or biochemical evidence of significant anemia, gastrointestinal, cardiac, hepatic or renal disease will be excluded.
- Subjects with other medical problems may participate as long as the problems are stable.
- Subjects with active psychiatric disorders or past history of bariatric surgery
- Pregnant or lactating women will also be excluded from the study, due to possible risk to the fetus or infant.
Key Trial Info
Start Date :
August 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2025
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04708535
Start Date
August 1 2017
End Date
August 1 2025
Last Update
December 4 2024
Active Locations (1)
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1
Stanford University
Stanford, California, United States, 94305