Status:
RECRUITING
University of Pittsburgh Brain Health Initiative
Lead Sponsor:
David Okonkwo, MD, PhD
Collaborating Sponsors:
National Football League Scientific Advisory Board
Avid Radiopharmaceuticals, Inc.
Conditions:
Traumatic Brain Injury
Eligibility:
MALE
29-59 years
Brief Summary
This project will define the prevalence of brain health (i.e., normal cognitive, neuromotor, behavioral function) in living professional football retirees and group-matched controls through a comprehe...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Former professional football player/exposed group:
- Professional football retiree aged 29-59
- Played a minimum of 3 professional football seasons, with a minimum of 3 games in each season
- Fluent in English (translations are not available/validated for most neuropsychological tests)
- Control/unexposed group:
- Age 29-59 male
- High school education or beyond
- Fluent in English (translations are not available/validated for most neuropsychological tests)
- Exclusion criteria:
- Control/unexposed group:
- Played organized football beyond high school
- History of severe TBI
- Current unstable cardiovascular disorder
- For both groups:
- Prior history of psychosis (such as schizophrenia), or other major neurological disorder that would interfere with testing, in the opinion of the primary investigator.
- Contraindication to MR imaging, such as ferrous metal, pacemakers, or concerns about claustrophobia
Exclusion
Key Trial Info
Start Date :
November 18 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT04708613
Start Date
November 18 2019
End Date
December 1 2026
Last Update
June 13 2025
Active Locations (1)
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1
University of Pittsburgh Department of Neurosurgery
Pittsburgh, Pennsylvania, United States, 15213