Status:
COMPLETED
A Drug Interaction Study of ACH-0145228
Lead Sponsor:
Alexion Pharmaceuticals, Inc.
Collaborating Sponsors:
Achillion, a wholly owned subsidiary of Alexion
Celerion
Conditions:
Healthy
Eligibility:
All Genders
18-55 years
Phase:
PHASE1
Brief Summary
This was a 2-part study (Part 1 and Part 2), with each part being an open-label, fixed sequence, 2-period study in healthy adult participants.
Eligibility Criteria
Inclusion
- Body mass index in the range of 18.0 to 32.0 kilograms (kg)/meter squared, inclusive, with a minimum body weight of 50.0 kg at screening.
- No clinically significant history or presence of electrocardiogram abnormalities at screening and prior to first dosing in Period 1.
- Non-sterile male participants must agree to abstinence or use a highly effective method of contraception.
- Female participants must be of non-childbearing potential and need not employ a method of contraception.
Exclusion
- Clinically significant laboratory abnormalities.
- History of any medical or psychiatric condition or disease that might limit the participant's ability to complete or participate in this clinical study, confound the results of the study, or pose an additional risk to the participant by their participation in the study.
- History or presence of drug or alcohol abuse within previous 2 years, current tobacco/nicotine user, or positive for alcohol and/or drug screen at screening or Day -1 of Period 1.
- History or presence of clinically significant seizures, head injury, or head trauma.
- History of procedures that could alter absorption or excretion of orally administered drugs.
- A history of significant multiple and/or severe allergies or has had an anaphylactic reaction or significant intolerability to prescription or non-prescription drugs.
- Body temperature ≥ 38.0°Celsius at screening or prior to first dosing in Period 1.
- Donation of whole blood from 3 months prior to first dosing, or of plasma from 30 days before first dosing, or receipt of blood products within 6 months prior to first dosing.
- Participation in any other investigational study drug trial in which receipt of an investigational study drug occurred within 5 half-lives (if known) or 30 days before first dosing, whichever is longer.
- History or presence of any risk factors for Torsades de Pointes.
Key Trial Info
Start Date :
December 22 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 16 2020
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT04709081
Start Date
December 22 2019
End Date
April 16 2020
Last Update
January 14 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Clinical Study Site
Tempe, Arizona, United States, 85283