Status:
RECRUITING
CT Stress Myocardial Perfusion, Fractional Flow Reserve and Angiography in Patients With Stable Chest Pain Syndromes
Lead Sponsor:
Rigshospitalet, Denmark
Conditions:
Coronary Artery Disease
Chest Syndrome
Eligibility:
All Genders
Phase:
NA
Brief Summary
The purpose of the DYNAMITE trial (Dynamic CT stress myocardial perfusion, CT fractional flow reserve (FFR-CT) and coronary CT angiography for optimized treatment strategy in patients with chest pain ...
Detailed Description
Trial design The DYNAMITE trial is an investigator-initiated, randomised controlled, open-labelled trial conducted in the Capital Region of Copenhagen, Denmark The following hypothesis will be teste...
Eligibility Criteria
Inclusion
- Chest pain in patients with clinically suspected or confirmed ischemic heart disease
- Clinical indication for non-acute coronary evaluation
- Status of coronary revascularization
- With previous coronary revascularization - all patients
- Without previous coronary revascularization
- Age≥65 years - all patients with chest pain
- Age\>50 - \<65 years - typical angina pectoris and at least one cardiovascular risk factor and/or previous myocardial infarction
- Typical angina requiring all 3 criteria present: a) constrictive discomfort in the front of the chest or in the neck, jaw, shoulder or arm, b) precipitated by physical exertion c) relieved by rest or nitrates within 5 min.
- Cardiovascular risk factors: hypertension, diabetes, hypercholesterolemia, current smoking, family history of ischemic heart disease, previous stroke, peripheral artery disease
Exclusion
- Persistent chest pain and signs of ongoing acute myocardial ischemia requiring acute coronary intervention
- Hospitalization and discharge with the confirmed diagnosis acute coronary syndrome (STEMI or NSTEMI) within the last 6 months
- Severe valvular heart disease as primary diagnosis and/or in potential need of percutaneous or surgical valve treatment
- Known severe heart failure (LVEF less than 35%)
- Language, cultural or mental factors preventing the patient from understanding the informed consent form
- Known atrial fibrillation
- Known renal impairment (estimated Glomerular Filtration Rate below \<30 ml/min)
- Known x-ray contrast allergy
- Known intolerance to adenosine infusion
Key Trial Info
Start Date :
December 3 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2031
Estimated Enrollment :
2000 Patients enrolled
Trial Details
Trial ID
NCT04709900
Start Date
December 3 2021
End Date
December 1 2031
Last Update
December 12 2022
Active Locations (1)
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1
Department of Cardiology and Radiology, Rigshospitalet, The Heart Center, Capital Region of Copenhagen, University of Copenhagen
Copenhagen, Denmark, 2100