Status:
COMPLETED
Physiologic Effects of High-flow Nasal Cannula Versus Standard Oxygen Therapy Postextubation in Critically Ill Patients
Lead Sponsor:
Pontificia Universidad Catolica de Chile
Collaborating Sponsors:
Fondo Nacional de Desarrollo Científico y Tecnológico, Chile
Conditions:
Ventilator Weaning
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
High-flow nasal cannula (HFNC) is a rather novel system to provide oxygen therapy, which provides flows up to 60 liters/minute (LPM) of heated and humidified gas through nasal prongs. HFNC is increasi...
Eligibility Criteria
Inclusion
- Mechanical ventilation (MV) through an orotracheal tube for at least 48 hours
- PaO2 /FiO2 ratio ≤ 300 mmHg
- Potential for weaning as determined in routine daily screening (precipitating cause leading to MV in resolution, adequate oxygenation (PaO2/FiO2 ≥150 mmHg with FiO2 ≤0.4 and PEEP ≤8 cm H2O), arterial pH \>7.25, hemodynamic stability (no vasopressors or Noradrenaline ≤0.1 mcg/kg/min), temperature \<38°C, presence of inspiratory effort and appropriate spontaneous cough, and the patient is not receiving sedatives and is awake and able to follow simple commands)
- Decision to perform a spontaneous breathing trial by the attending physician
Exclusion
- Patients ventilated for decompensated chronic obstructive pulmonary disease
- Contraindications to HFNC, which include abnormalities or surgery of the face, nose, or airway that preclude an appropriate-fitting nasal cannula.
- Contraindications for esophageal balloon catheter insertion (eg. severe coagulopathy, esophageal varices, and history of esophageal or gastric surgery)
- Contraindication for use of electric impedance tomography (eg. Pacemaker)
- Presence of tracheostomy
- Refusal to participate by the attending physician
- Do not resuscitate order
Key Trial Info
Start Date :
January 27 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 17 2022
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT04711759
Start Date
January 27 2021
End Date
December 17 2022
Last Update
January 13 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Hospital Clínico UC Christus
Santiago, Santiago Metropolitan, Chile, 114D