Status:
COMPLETED
Effects of Oral Pre-loads on Subsequent Energy Intake
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Energy Intake
Gastrointestinal Hormones
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
The aim of this project is to investigate the effect of erythritol (given as pre-load), compared to sucrose, sucralose, and water on energy intake during a subsequent ad libitum test meal in healthy p...
Detailed Description
The subjects will participate in four study days. The screening will last 60 minutes, the study days about 4.5 hours each. After a simple-carbohydrate standard dinner, the subjects have to do an overn...
Eligibility Criteria
Inclusion
- Healthy normal weight subjects with a body-mass index of 19.0-24.9
- Normal eating habits (eating breakfast; no diets; no dietary changes; no vegetarians/vegans, no intolerances/allergies)
- Age 18-55 years
- Stable body weight (+/- 5%) for at least three months
- Informed Consent as documented by signature (Appendix Informed Consent Form)
Exclusion
- Shift worker
- Fructose intolerance
- Pre-existing consumption of erythritol and/or sucralose more than once a week
- Substance abuse
- Regular intake of medications, except anticontraceptive
- Chronic or clinically relevant acute infections
- Pregnancy: although no contraindication, pregnancy might influence metabolic state. Women who are pregnant or have the intention to become pregnant during the course of the study are excluded. Female participants of childbearing age have to use safe contraception (oral, injectable, or implantable contraceptives, intrauterine contraceptive devices, or tubectomy). In female participants a urine pregnancy test is carried out upon screening.
- Participation in another study with investigational drug within the 30 days preceding and during the present study.
Key Trial Info
Start Date :
February 5 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 3 2021
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04713137
Start Date
February 5 2021
End Date
June 3 2021
Last Update
December 16 2021
Active Locations (1)
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1
St. Claraspital
Basel, Switzerland, 4002