Status:
COMPLETED
Low-dose Intravenous Dexamethasone at Different Times as Adjunvants for Brachial Plexus Blocks
Lead Sponsor:
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Conditions:
Analgesia
Dexamethasone
Eligibility:
All Genders
18-70 years
Phase:
PHASE4
Brief Summary
Dexamethasone has been tested as an effective adjuvant to prolong the effect of local anesthetics for peripheral nerve blocks, both perineurally and intravenously. The purpose of this study is to inve...
Detailed Description
Interscalene brachial plexus block (ISB) is regarded as the standard of care for anesthesia and analgesia for shoulder surgery by providing the superior analgesia and reducing opioid consumption. Afte...
Eligibility Criteria
Inclusion
- Patients undergoing arthroscopic shoulder surgery at Shanghai Sixth People's Hospital.
- ASA functional status class I to II
- Age 18 to 70 years
- BMI ≤ 35 kg/m2
Exclusion
- Lack of patient consent
- Allergy to dexamethasone or ropivacaine
- BMI \> 35 kg/m2
- Contraindications to low dose dexamethasone including peptic ulcer disease, systemic infection, glaucoma, active varicella/herpetic infections, diabetes mellitus
- Contraindications to ISB including severe Chronic Obstructive Pulmonary Disease (Forced expiratory volume \< 40% predicted), coagulopathy, pre-existing neurologic deficit in ipsilateral upper extremity, localized infection
- Pregnant or nursing females
- Chronic opioid use defined as \> 30mg oral morphine or equivalent per day
Key Trial Info
Start Date :
January 10 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2021
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT04714112
Start Date
January 10 2021
End Date
July 31 2021
Last Update
January 26 2023
Active Locations (1)
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1
Shanghai Jiaotong University affiliated Shanghai Sixth People's Hospital
Shanghai, China