Status:
COMPLETED
Blood Markers Predict Effect of Normobaric Hypoxia at Rest and During Exercise in Patients With Pulmonary Hypertension
Lead Sponsor:
University of Zurich
Conditions:
Hypertension, Pulmonary
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
To study the effect of acute normobaric hypoxia during exercise in patients with pulmonary hypertension on blood markers (serum markers of iron and red blood cell homeostasis and micro-RNAs known to b...
Eligibility Criteria
Inclusion
- Informed consent as documented by signature (Appendix Informed Consent Form)
- PH class I (PAH) or IV (CTEPH) diagnosed according to guidelines: mean pulmonary artery pressure \>20 mmHg, pulmonary vascular resistance ≥3 wood units, pulmonary arterial wedge pressure ≤15 mmHg during baseline measures at the diagnostic right-heart catheterization
Exclusion
- resting partial pressure of oxygen \<8 kilopascal at Zürich altitude on ambient air
- exposure to an altitude \>1000 m for ≥3 nights during the last 2 weeks before the study
- inability to follow the procedures of the study
- patients who take nitrates
- other clinically significant concomitant end-stage disease (e.g., renal failure, hepatic dysfunction)
Key Trial Info
Start Date :
February 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 31 2023
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT04715113
Start Date
February 1 2021
End Date
May 31 2023
Last Update
June 6 2023
Active Locations (1)
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1
University Hospital of Zurich
Zurich, Switzerland, 8091