Status:
UNKNOWN
Myeloid Cells in Aortic Valve Stenosis
Lead Sponsor:
Radboud University Medical Center
Conditions:
Aortic Valve Disease
Aortic Valve Stenosis
Eligibility:
All Genders
18+ years
Brief Summary
Investigators plan to characterize systemic inflammation and circulating immune cells in participants with moderate and severe calcific aortic valve disease and matched healthy controls.
Detailed Description
Calcific aortic valve disease (CAVD) is the most common type of valvular heart disease in the Western world. Due to the aging of the population, the impact of this disorder is expected to further incr...
Eligibility Criteria
Inclusion
- Age \> 18 years
- Mild, moderate or severe degenerative aortic valve stenosis as defined by transthoracic echocardiography according to the 2017 ESC/EACTS guidelines for the management of valvular heart disease.
Exclusion
- Active auto-inflammatory or auto-immune diseases
- Anti-inflammatory drugs
- Vaccination less than one month before inclusion
- Bone marrow transplantation
- Active malignancy, except for local basal cell carcinoma or local squamous cell skin carcinoma, that can be treated curatively by excision.
- History of endocarditis of the aortic valve
- History of radiation therapy aimed at the chest
- Acute ischemic cardiac event less than three months before inclusion
- Systemic inflammation less than one month before inclusion with fever and/or for which antibiotics have been prescribed, with the exception for the use of nitrofurantoin for a urinary tract infection without fever
Key Trial Info
Start Date :
November 19 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT04717219
Start Date
November 19 2020
End Date
December 31 2022
Last Update
April 12 2022
Active Locations (3)
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1
Rijnstate
Arnhem, Netherlands
2
Radboud university medical center
Nijmegen, Netherlands, 6500 GA
3
Canisius Wilhelmina Ziekenhuis
Nijmegen, Netherlands