Status:
COMPLETED
Exercise, Milk Thistle, and Lactobacillus to Influence Plasma Bilirubin
Lead Sponsor:
Kyle Flack
Conditions:
Obesity
Eligibility:
All Genders
18-50 years
Phase:
PHASE3
Brief Summary
The proposed clinical trial will test our hypothesis that, during exercise, red blood cell (RBC) release of heme and catabolism to bilirubin is an essential process that mediates gene responses that r...
Detailed Description
The investigative team's previous work has shown that BR binds to the PPARalpha protein in fat and liver tissues to activate genes that improve fatty acid oxidation via a hormone known as fibroblast g...
Eligibility Criteria
Inclusion
- Classified as obese (BMI 30-45)
- Sedentary (do not currently exercise)
- Aged 18-50 years
- Without contraindications to exercise
Exclusion
- Dieting for weight control
- Tobacco users
- Have a ragweed allergy
- Taking antibiotics, hypoglycemic agents, anticoagulants, statins, or NSAIDs
- Nursing, pregnant, or planning on becoming pregnant
- Supplementing with a probiotic
Key Trial Info
Start Date :
February 24 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 19 2023
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT04717726
Start Date
February 24 2021
End Date
July 19 2023
Last Update
July 28 2023
Active Locations (1)
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1
University of Kentucky- Nutrition Assessment Lab
Lexington, Kentucky, United States, 40506