Status:
COMPLETED
The Modulatory Role of Communicated Treatment Rationale on Treatment Expectation Effects in Depression.
Lead Sponsor:
Philipps University Marburg
Collaborating Sponsors:
Psychotherapie-Ambulanz Marburg e.V.
Conditions:
Condition: Major Depressive Disorder (MDD)
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Placebo groups in clinical trials on depression show impressive improvements. Yet, there is little research on the mechanism underlying this effect. The aim of this study is to assess how patients' tr...
Eligibility Criteria
Inclusion
- Diagnosis of major depression according to the 'Structured Clinical Interview for DSM-V' (SCID)
- Age\>17
- Comorbidity is allowed if major depression is the dominant clinical problem
- Concordant medication is allowed if kept constant for the four weeks before and until the end of the trial (with the exception of benzodiazepines and if not contraindicated together with Buscopan)
- Fluency in German
- Informed consent
Exclusion
- Severe depression (BDI\> 30) or suicidality
- Psychosis
- Significant neurological diseases
- Other mental or physical disorder with substantial influence on disability
- Benzodiazepine intake
- Any intolerance against Buscopan and sucrose or any medical condition/treatment conflicting with Buscopan intake
Key Trial Info
Start Date :
April 13 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 12 2023
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT04719663
Start Date
April 13 2021
End Date
September 12 2023
Last Update
November 18 2023
Active Locations (1)
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1
Department of Clinical Psychology and Psychotherapy, Philipps-University Marburg
Marburg, Germany, 35032