Status:
RECRUITING
Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study
Lead Sponsor:
Yale University
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Cocaine Use Disorder
Healthy Controls
Eligibility:
All Genders
21-60 years
Brief Summary
The purpose of this research study is to measure synaptic density in the brain comparing individuals with cocaine use disorder to healthy controls.
Detailed Description
Healthy controls (HC) will be studied as outpatients and undergo one MRI and one 11C-UCB-J PET scan, along with neurocognitive tasks. Individuals with Cocaine Use Disorder (CUD) will complete the stud...
Eligibility Criteria
Inclusion
- Age 21-60 years
- Physically healthy by medical history, physical, neurological, ECG and laboratory examinations
- For females, a negative serum pregnancy test
- For CUD: DSM-5 criteria for Cocaine Use Disorder and positive urine toxicology showing recent use
- For HC: Negative urine toxicology
Exclusion
- DSM-5 criteria for other substance use disorders (e.g., alcohol, opiates, sedative hypnotics), except for nicotine
- A primary DSM-5 Axis I major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depression, etc.) as determined by the Structured Clinical Interview for DSM-5 (SCID-5)
- A history of significant and/or uncontrolled medical or neurological illness
- Current use of psychotropic and/or potentially psychoactive prescription medications
- Medical contraindications to MRI procedure
Key Trial Info
Start Date :
July 20 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04721418
Start Date
July 20 2021
End Date
June 1 2026
Last Update
September 11 2025
Active Locations (1)
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1
Connecticut Mental Health Center
New Haven, Connecticut, United States, 06519