Status:
UNKNOWN
Impact of CBD-Rich Oil on Aversive Memory Reconsolidation
Lead Sponsor:
University of Texas at Austin
Conditions:
Anxiety and Fear
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose of this study is to test whether cannabidiol (CBD) rich hemp extract oil can interfere with the reconsolidation (storage) of pathological fear memory in humans.
Detailed Description
Preclinical experiments demonstrate that isolated cannabidiol (CBD), the non-psychotomimetic constituent of the Cannabis sativa plant, disrupts reconsolidation of aversive memories conditioned in the ...
Eligibility Criteria
Inclusion
- Inclusion criteria include:
- Ages 18-65
- Fluent in English
- Willingness to refrain from all non-study cannabis use during the study period.
- Exclusion criteria include:
- Insufficient phobicity (\<50 on CO2 challenge);
- Presence of significant suicidality;
- History of psychosis;
- Currently receiving exposure-based treatment;
- Current substance use disorder;
- Unstable psychiatric medication for a psychological condition;
- Medical conditions contraindicating CO2 inhalation (e.g., cardiac arrhythmia, cardiac failure, asthma, lung fibrosis, high blood pressure, epilepsy, or stroke);
- Any medical problems (e.g., liver or renal abnormalities) or medication use that would preclude ingesting CBD oil, including but not limited to currently taking blood thinners (e.g., Warfarin and some anti-epileptic medications);
- History of an adverse reaction to CBD oil or other CBD products,
- Coconut allergy (coconut oil is the carrier oil for CBD-rich extract)
- (l) Regular cannabis use
Exclusion
Key Trial Info
Start Date :
January 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2024
Estimated Enrollment :
96 Patients enrolled
Trial Details
Trial ID
NCT04726475
Start Date
January 1 2022
End Date
January 1 2024
Last Update
January 19 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Texas
Austin, Texas, United States, 78712