Status:
COMPLETED
Optimal Dosage of Acetazolamide for OSA Treatment
Lead Sponsor:
University Hospital, Antwerp
Conditions:
Obstructive Sleep Apnea
Eligibility:
All Genders
18-79 years
Phase:
PHASE4
Brief Summary
Acetazolamide, a carbonic anhydrase inhibitor, has received some attention as potential treatment for obstructive sleep apnea (OSA). It produces a metabolic acidosis by excreting bicarbonate, thereby ...
Detailed Description
In this double-blind, parallel-group, controlled trial, eligible patients will be randomized into one of the following treatment arms: (1) placebo, (2) 250 mg of acetazolamide, or (3) 500 mg of acetaz...
Eligibility Criteria
Inclusion
- AHI between 15 and 65 events/hour
- BMI \< 35 kg/m²
Exclusion
- Craniofacial anomalies
- Central sleep apnea (defined as central AHI \> 25% of total AHI)
- Contra-indications related to acetazolamide treatment
- Hypersensitivity to sulphonamides or acetazolamide
- Renal impairment, electrolyte imbalances, and/or adrenocortical insufficiency
- Clinically significant metabolic, hepatic, and/or hematological disease
- Chronic obstructive pulmonary disease
- Closed-angle glaucoma
- Conditions likely to affect OSA physiology: neuromuscular disease or other major neurological disorders, heart failure, or any other unstable major medical condition.
- Intake of drugs that substantially stimulate or depress respiration, including benzodiazepines, opioids, theophylline, and pseudoephedrine
- Inadequately treated sleep disorders other than OSA that would confound functional sleep assessment
- Inability of the patient to understand and/or comply to the study procedures
- Active psychiatric disease (psychotic illness, major depression, anxiety attacks, alcohol or drug abuse)
- Pregnancy
Key Trial Info
Start Date :
April 20 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 5 2024
Estimated Enrollment :
91 Patients enrolled
Trial Details
Trial ID
NCT04726982
Start Date
April 20 2021
End Date
May 5 2024
Last Update
September 24 2025
Active Locations (1)
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1
Antwerp University Hospital
Edegem, Antwerp, Belgium, 2650