Status:
ACTIVE_NOT_RECRUITING
Consumption of Oral Artificial Sweeteners on Platelet Aggregation and Polyol Excretion
Lead Sponsor:
The Cleveland Clinic
Conditions:
Cardiovascular Risk Factor
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The principal goal for the study is to examine whether ingestion of a beverage containing artificial sweeteners alters in vitro platelet aggregation. Because of the increasing number of cardiometabol...
Detailed Description
The purpose of this study is to examine if drinking a single beverage that contains an artificial sweetener can perceptibly alter the activity of platelets in the body. Platelets are a component of bl...
Eligibility Criteria
Inclusion
- Cohort 1
- Age 18 years or above.
- Willing and able to sign the consent form.
- Cohort 1
Exclusion
- Use of anti-platelet medications within 14 days of study enrollment.
- Active infection or received antibiotics within 1 month of study enrollment.
- Use of over-the-counter probiotic within 1 month of study enrollment.
- Diabetes mellitus
- Ulcerative colitis, Crohn's disease, or other chronic gastrointestinal disorder.
- Past history of bariatric procedures or surgeries (e.g. gastric banding or bypass).
- Pregnancy.
- Significant chronic illness.
- Cohort 2 Inclusion Criteria:
- Men and women age 18 years or above.
- Able to provide informed consent and comply with study protocol.
- Diabetes Mellitus Type II
- Cohort 2
Key Trial Info
Start Date :
March 10 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2025
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04731363
Start Date
March 10 2021
End Date
December 1 2025
Last Update
June 11 2025
Active Locations (1)
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1
Cleveland Clinic
Cleveland, Ohio, United States, 44195