Status:
COMPLETED
Evaluation of Post-operative Pain and Expression of IL-8 Using Ketolac or Cryoirrigation as a Final Flush in Single Visit Endodontic Treatment in Teeth With Symptomatic Irreversible Pulpitis and Apical Periodontitis.Randomized Clinical Trial.
Lead Sponsor:
Cairo University
Conditions:
Post-operative Pain
Eligibility:
All Genders
18-40 years
Phase:
PHASE1
Brief Summary
To compare the effect of cryotherapy versus ketorolac tromethamine irrigating solutions used as a final flush in single visit endodontic treatment in mandibular molars, with symptomatic irreversible p...
Detailed Description
The main rationale of endodontic treatment is to eliminate micro-organisms from the infected root canal system by adequate chemo-mechanical debridement followed by a three-dimensional hermetic seal to...
Eligibility Criteria
Inclusion
- \- Medically free patients
- Age between 18-40 years old
- Males or females
- Participants able to understand Visual Analogue Scale (the pain chart diary) and sign the informed consent ( Appendix I,II).
- Mandibular permanent molar teeth:
- Diagnosed clinically with symptomatic irreversible pulpitis associated with apical periodontitis.
- Presence of spontaneous pain and sharp pain to cold tester (ethyl-chloride) that lingers after removal of the stimulus compared to the contra-lateral tooth
- Tenderness to percussion with normal periapical radiographic appearance or slight widening of the lamina dura
Exclusion
- \- Participants allergic to NSAIDS
- Pregnant females
- Participants having significant systemic disorder
- If analgesics or antibiotics have been taken by the patient during the past 24 hours pre-operatively.
- Participants with psychological disturbances
- Participants with bruxism or clenching
- Participants having acute pain in more than one mandibular molar
- Participants with mandibular molar teeth showing:
- Swelling or fistulous tract
- Acute or chronic periapical abscess
- Mobility greater than grade I
- Periodontitis
- Previous endodontic treatment or non-restorability
Key Trial Info
Start Date :
September 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2023
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT04733326
Start Date
September 1 2021
End Date
March 1 2023
Last Update
September 19 2024
Active Locations (1)
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1
Faculty of dentistry, Cairo univresity
Giza, Egypt, 11211